目前，全球及中國糖尿病肥胖等代謝疾病的發(fā)病率越來越高，越來越需要我們認(rèn)真去研究對待，因此對糖尿病肥胖等代謝疾病的研究越來越多。

     該研究一般以大小鼠為實(shí)驗(yàn)對象，通過大小鼠的呼吸商（即呼入氧氣和呼出二氧化碳的比值）來對大小鼠的能量消耗進(jìn)行評估，除此之外可能需要給大小鼠提供喂食飲水，并對喂食飲水進(jìn)行量和次數(shù)的監(jiān)測，也需要對其尿液進(jìn)行收集，也需要同時(shí)監(jiān)測活動(dòng)情況，體重 心率等功能的監(jiān)測。

       國內(nèi)外現(xiàn)在對糖尿病和肥胖營養(yǎng)等疾病研究越來越深入：以下是一些相關(guān)的文章做參考：

客戶名稱	作者	發(fā)表文章	收錄雜志
南京大學(xué)模式動(dòng)物中心	高翔	Interaction of MAGED1 with nuclear receptors affects circadian clock function	EMBO Journal
中科院營養(yǎng)所	郭非凡	Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue	Diabetes
		ATF4 regulates lipid metabolism and thermogenesis	CELL RESEARCH
中科院營養(yǎng)所	劉勇	Abrogation of Hepatic ATP-Citrate Lyase Protects Against Fatty Liver and Ameliorates Hyperglycemia in Leptin Receptor-Deficient Mice	HEPATOLOGY
		Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis	PNAS美國科學(xué)院院刊
		Signaling through Tyr985 of Leptin Receptor as an Age/Diet-Dependent Switch in the Regulation of Energy Balance	MOLECULAR AND CELLULAR BIOLOGY

A high-fat, ketogenic diet induces a unique metabolic state in mice

Adam R. Kennedy,¹ Pavlos Pissios,¹ Hasan Otu,² Bingzhong Xue,¹ Kenji Asakura,¹ Noburu Furukawa,¹ Frank E. Marino,¹ Fen-Fen Liu,¹ Barbara B. Kahn,¹ Towia A. Libermann,² and Eleftheria Maratos-Flier¹Am J Physiol Endocrinol Metab 292: E1724-E1739, 2007

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

Alexander V. Mayorov^a,b, Neri Amara^c, Jason Y. Chang^a,b, Jason A. Moss^a,b Mark S. Hixon^a,b, Diana I. Ruiz^a,b, Michael M. Meijler^c,1, Eric P. Zorrilla^d,e,1, and Kim D. Janda^a,b,f,g,1
PNAS November 11, 2008 vol. 105 no. 45 17487-17492

A Novel Method for High Throughput Phenotyping of Sleep in Mice

Allan I Pack¹*, Raymond J. Galante², Greg Maislin¹, Jacqueline Cater², Dimitris Metaxas³, Shan Lu³, Lin Zhang², Randy Von Smith⁴, Timothy Kay², Jie Lian², Karen Svenson⁴, and Luanne L Peters⁵Physiol. Genomics (September 19, 2006). doi:10.1152/physiolgenomics.00139.2006

Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor

Andrea Frassetto^a, Jiaping Zhang^a, Julie Z. Lao^a, Amanda White^b, Joseph M. Metzger^b, Tung M. Fong^a and Richard Z. Chen^a

Brain Research Volume 1236, 21 October 2008, Pages 140-144

Hemodynamic effects of substance P and its receptor antagonist RP67580 in anesthetized rats with carbon tetrachloride-induced cirrhosis

Andres Cardenas ^ab; Robert Lowe ^c; Sangik Oh ^a; Sheila Bodkin ^c; Tom Kenney ^c; Wayne W. Lamorte ^d; Nezam H. Afdhal ^a
Scandinavian Journal of Gastroenterology, Volume 43, Issue 3 2008 , pages 328 - 333

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