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Anti Caspase-3 active
英文名稱:Anti Caspase-3 active總訪問:123
國產(chǎn)/進(jìn)口:進(jìn)口半年訪問:5
產(chǎn)地/品牌:美國產(chǎn)品類別:分子生物學(xué)試劑
規(guī)       格:0.1mg 最后更新:2025-2-19
貨       號(hào):CAS3PU
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CD3 is a member of the immunoglobulin superfamily, which acts as a mediator of signal transduction, through association with the α/β or γ/δ T-cell receptor (TCR). Mammalian CD3 is a multimeric protein composed of four distinct polypeptide chains (ε, γ, δ, ζ), consisting of two heterodimers (εγ, εδ) and one homodimer (ζζ). CD3 is expressed by a high-percentage of circulating peripheral T-cells and is considered a pan T-cell marker. Clone UCHT1 specifically recognizes the 20kDa CD3ε chain.

CD4 is a single chain transmembrane glycoprotein and member of the immunoglobulin superfamily, which interacts directly with class II molecules of the major histocompatibility complex (MHCII), and is the primary receptor for the human immunodeficiency virus (HIV). CD4 is expressed by the helper/inducer (CD3+CD4+) T-cell subset, the majority of thymocytes, and at low levels by monocytes and tissue macrophages. The CD4 lymphocyte count provides an excellent indication of immune system health. Clone RPA-T4 binds to the D1 domain (CDR1 and CDR3 epitopes) of the CD4 antigen.

CD62L is present on 61% to 75% of normal human peripheral blood lymphocytes, 70% to 80% of E-rosetting cells, 10% of thymocytes, and most B lymphocytes. CD62L identi?es regulatory subpopulations of T lymphocytes in both the CD8+ and CD4+ subsets. Approximately 75% of CD4+ T lymphocytes also bear the CD62L antigen. CD4+ CD62L– lymphocytes mediate the majority of helper functions involved in B-lymphocyte differentiation into plaque-forming cells, whereas the suppressor inducer functional subpopulation is included in the CD4+CD62L+ compartment. Approximately 60% of CD8+ T lymphocytes are recognized by CD62L.

CD45RA is expressed by na?ve T-cells, but not by activated and memory T-cells. CD45RA is an isoform of CD45, a member of the protein tyrosine phosphatase family, otherwise known as leucocyte common antigen (LCA), which acts as a positive regulator of T-cell co-activation, and is essential for the activation of T-cells through the antigen receptor. CD45RA is expressed by na?ve T-cells and is down-regulated during activation.
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