安捷倫“真核轉(zhuǎn)錄調(diào)控”技術(shù)交流會
Eukaryotic Transcriptional Regulatory Networks: Dr. Tony Lee of MIT

地點:北京大學一生命科學學院一新生命科學大樓報告廳(一層)
時間:2006年6月20日
Schedule
1.10:00-10:05
Introduction:Shuolin SONG, Ph.D. Asia Pacific Marketing Manager, AgilentTechnologies
2.10:05-11:00
Eukaryotic Transcriptional Regulatory Networks : Dr.Tony Lee of MIT

Bio of Dr.Tony Lee:
Tony Lee has a Ph.D. degree from the Massachusetts Institute of Technology and a B.A. from Harvard College. He has been at the Whitehead Institute since 1994 and currently holds the title of Research Scientist. He has co-authored several papers in the fields of transcriptional regu-lation and led several of the pioneering efforts on genome-wide expression and chromatin immunoprecipitation technology in the laboratory of Richard Young.

Abstract:
Genome sequences encode the gene expression programs that contribute to development and differentiation, but how the cell controls global gene expression programs is far from understood. With the availability of complete genome sequences and a method for locating proteins on a genome-wide scale, we are now in the process of building regulatory networks including transcription factors. Chromatin modifying factors and other cellular components in several model systems Human ES cells, which can be maintained in an undifferentiated state but selectively induced to differentiate into specialized cell types, are thought to hold great promise for regenerative medicine. Polycomb group proteins are a subset of proteins previously identified as essential for early development in metazoans but their contributions to the gene expression programs that control development and ES cell identity are still unclear. We have now mapped the Polycomb Repressive Complex 2 (PRC2) subunit Suz12 across the entire non-repeat portion of the genome in human ES cells. We found that Suz12 is distributed across large portions of overtwo hundred genes encoding key developmental regulators. PRC2 target genes are preferentially activated during ES cell differentiation and the ES cell regulators Oct4, Sox2 and Nanog co-occupy a significant subset of these genes. These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotencyand that are poised for activation during ES cell differentiation.

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