26 次染色質(zhì)開放性測(cè)序(ATAC-seq)原理以及應(yīng)用領(lǐng)域 2025-4-30
技術(shù)簡(jiǎn)介染色質(zhì)開放性測(cè)序(Assay for Transposase-Accessible Chromatin using sequencing,ATAC-seq),一種用于檢測(cè)染色質(zhì)開放性的高通量測(cè)序技術(shù),通過Tn5轉(zhuǎn)座酶切割并標(biāo)記開放的染色質(zhì)區(qū)域
48 次ATAC-seq開啟新視角:探索Shox2基因沙漠的神秘功能 2025-4-30
2024年7月,發(fā)表在《Nature Communications》的一篇文章“A gene desert required for regulatory control of pleiotropic Shox2 expression and embryonic survival”,聚焦Shox2基因
151 次內(nèi)皮雌激素-心肌cGMP軸決定壓力超負(fù)荷期間的血管生成和心臟功能 2025-4-28
Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overloadKeywords: Angiogenesis; Cycl
144 次GSPT1作為黃金靶點(diǎn)在腫瘤治療領(lǐng)域的作用及應(yīng)用案例分享 2025-4-28
引言GSPT1(G1 to S phase transition 1),作為人類基因組中的一個(gè)基因,編碼了一種重要的蛋白質(zhì),該蛋白質(zhì)在細(xì)胞蛋白質(zhì)合成的翻譯終止過程中扮演著關(guān)鍵角色。近年來,隨著生物技術(shù)和藥物研發(fā)的
180 次機(jī)械拉伸誘導(dǎo)的活性氧驅(qū)動(dòng)新生豬腎上皮細(xì)胞內(nèi)皮素的產(chǎn)生 2025-4-27
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cellsKeywords: Acute kidney injury; Endothelin; Endothelin
212 次Hes1/Piezo1 通路在糖皮質(zhì)激素誘導(dǎo)的骨質(zhì)疏松癥中的關(guān)鍵作用 2025-4-22
The pivotal role of the Hes1/Piezo1 pathway in the pathophysiology of glucocorticoid-induced osteoporosisKeywords: Bone biology; Bone disease; Osteoporosis; Therapeutics.糖皮質(zhì)激素